Doxycycline Ruined My Life (Severe Side Effects, Warnings & Drug Interactions)

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Doxycycline is a generic drug used to treat antiviral infections, malaria, and even severe acne. It’s mainly prescribed as part of combination treatment with other medications. This drug comes with many warnings, a list of severe side effects, possible allergic reactions, or food interactions one needs to be aware of. One also needs to be aware of possible drug interactions and how to take this medicine. If you’re not being careful, you might face the severe effect of this drug. There’re various warning signs and when you become aware of them, immediately seek help before things get worse. 

Doxycycline oral tablet is a prescription drug but is widely known as brand-name drugs such as Acticlate, Doryx, and Doryx MPC.

Be it a generic drug or brand-named drug; if you’re currently on it, it must be to treat a bacterial infection, severe acne, or prevent malaria.

But this drug is quite different, and it comes with a lot of warnings.

There are specific warnings, but severe side effects one might suffer from can probably affect one’s quality of life.

There’s also a possibility of drug interaction, making it a more sensitive drug that must be carefully administered.

This medication comes with many precautions, and one needs to know before deciding to take this medicine if it’s even worth it.

This can help you make a better decision before committing to this drug for long.

Who uses doxycycline?

When it comes to treating bacterial infection, doxycycline could be one of the medications prescribed by a doctor.

It’s pretty helpful in treating bacterial infections, including sexually transmitted diseases, skin infections, eye infections, respiratory infections, etc.

A young woman is using doxycycline to manage the her acne infection

It’s also used to treat acne infection and prevent malaria for those traveling to places with high malaria cases.

Doxycycline side effects

There’re some mild or common side effects such as:

  • Loss of appetite
  • Nausea and vomiting
  • Diarrhea
  • Rash
  • Sensitivity to the sun
  • Hives
  • Temporary discoloring of adult teeth 

Mild side effects stop or go away a few days after the medications are stopped. Such as the temporary discoloring can be cleaned out by the dentist

But it’s when these side effects don’t go away or become more advanced in nature then it becomes an issue.

Serious side effects include:

  • Antibiotic-associated diarrhea, which in itself has a list of severe symptoms such as painful or bloody diarrhea, stomach cramping or pain, fever, dehydration, loss of appetite, weight loss.
  • High blood pressure inside the skull with symptoms such as headache, blurry vision, double vision, and vision loss.
  • There can be irritation in the esophagus or ulcers with a burning or pain in the chest.
  • Anemia
  • Pancreatitis with pain in the upper abdomen, or pain abdomen which moves to back or gets worse after eating, and fever.
  • Severe skin reactions include blisters, peeling skin, or a rash of small purple spots.

With severe side effects like these, it’s best to call the emergency number right away and go to the nearest hospital for immediate treatment because of adverse effects.

Doxycycline warnings

This medication also comes with some warnings, and if you’re to ignore them, they might alarm you initially.

Not all those on this drug might experience these issues, but it’s better to be aware beforehand of these long-term effects so you know when to seek a doctor.

Permanent tooth discoloration

We talked about temporary tooth coloring, but there’s a serious warning about permanent tooth discoloring, which occurs in children if used during the tooth development stage.

If a pregnant mother takes them in the latter half of pregnancy or is given to a child in the tooth development stage, their teeth can permanently change color to yellow, gray, or brown.

Beware of diarrhea

A young man is experiencing diarrhea as a symptom of taking doxycycline

This drug has a severe warning of causing antibiotic-associated diarrhea.

This can either be mild or in severe form and ruin your day-to-day functioning as a human, and in rare cases, it can even lead to death.

Severe diarrhea isn’t meant to be taken lightly and isn’t something that should be waited for so it could pass. 

High blood pressure

This drug can also cause intracranial hypertension or high blood pressure inside the skull.

Symptoms include headache, blurry vision, double vision, and vision loss.

If you’re experiencing such symptoms, then don’t take things lightly. If not recognized or treated on time, it can also lead to swelling inside the eye. 

Women of childbearing age and overweight have a higher risk of this condition. 

Skin reactions

While you may be taking this drug to help with your severe acne, it can still lead to serious skin reactions.

These include Stevens-Johnson syndrome, toxic epidermal necrolysis, drug reaction with eosinophilia, and systemic symptoms (DRESS).

You’ll notice the following symptoms:

  • Blisters
  • Peeling skin
  • Rash or purple spots

Don’t wait for them to go away on their own and call the doctor right away.

Delayed bone growth

This medication can also delay bone growth in children if the mother takes them during her pregnancy.

Though it’s reversible and depends on when the mother stops taking them, the bone growth can go back to its normal pace. 


Taking this medication can also make you sensitive to sunlight.

Exposure to direct sunlight can lead to skin rash, itching, redness, or severe sunburn.

It’s best to use sunscreen and wear covered clothes when on this drug. 

Interactions with other drugs

Many oral medicines can have a drug interaction, and doxycycline is one.

Drug interaction with other medicines is impossible since this medication can’t be bought from the pharmacist without a prescription.

When meeting with your doctor, let them know your medical history and your current medicines, including anything herbal and the vitamins you must be taking.

This will help them prescribe better, so there’s no drug interaction.

Interaction can be explained in simple terms as changing the way a drug is supposed to work.

This can either lessen the effect of doxycycline or increase its side effects.

  • Drugs that you shouldn’t be using with doxycycline include Penicillin and Isotretinoin. 
  • Drugs that can make doxycycline less effective include antacids that contain aluminum, calcium, magnesium, bismuth subsalicylate, and iron-containing preparations. Seizure drugs such as barbiturates, carbamazepine, and phenytoin.
  • It can also increase side effects if interacted with warfarin.

Allergic reaction 

There’s a possibility of allergic reaction where the symptoms include trouble breathing and swelling of the throat or tongue.

And if there’s one allergic reaction, immediately stop taking it and never try to reintroduce it into your lifestyle, for it can be fatal and lead to death.

Food interaction

You would have never thought that food could also be on the list of warnings and considerations.

Food items containing calcium may block the amount of this drug absorbed by your body. And foods such as milk and cheese could create an issue and not let the drug work properly.

It is best to take all these items well before and after taking medicine. Keep a gap of an hour when eating this food and taking medicine. 

Taking doxycycline

Taking this drug also comes with a long list of do’s and don’ts because even the slightest delay in dosage or increase or decrease can result in harmful results. 

Of course, the dose of doxycycline and form depends on your age, the condition being taken for, how severe the condition is, other medical conditions, and how you react to the first dose.

There’re specific rules to follow when taking doxycycline.

The first is how you plan to take this medicine, and it’s best to take it with or without food.

With food, you’re less likely to feel nauseous or sick. But remember the consideration you must take with dairy products.

Follow the prescription given by the doctor to the point and don’t stop taking it suddenly, for it can result in fatal incidents.

Remember to take the drug on time and even if you forget, take the next dosage instead.

Try not to lay down for half an hour after taking this medicine.

Never try to compensate for the dosage missed as it can cause an excess drug to be present in the body resulting in severe side effects. 


Why do I feel worse on doxycycline?

Doxycycline needs some careful observation when taking it because of the number of warnings it comes with and the severe side effects it might result in.

It can be uneasy on your stomach and make you feel nauseated, accompanied by other mild side effects. But they should go away within a few days as your body adjusts to this drug.

It could also be a Jrisch-Herxheimer reaction.

This is caused when many bacteria are dying in the body, it worsens symptoms during the treatment, but this passes away soon.

Remember to take this medicine after food and not with a dairy item. Also, don’t lay down for half an hour after taking it. 

Does doxycycline affect mental health?

A study found that of 6000 reports of side effects from doxycycline, 91 involved psychosis or hallucinations.

Several cases have been reported where taking doxycycline within months or even days, and patients have a psychotic breakdown.

People suffer from a severe mental disorder where their thoughts and emotions lose touch with reality. They see things, hear voices, and lose control of their thoughts. 

But no studies or research show this ugly severe side effect of doxycycline. Nor is it listed in the warnings that come with this drug. 

To summarize

Doxycycline is a drug that comes with several warnings and precautions before someone starts taking it.

If you follow the rules and instructions, these sensitive medicines can do you no real harm. You might suffer from mild side effects, but they shall go away soon.

But sometimes, doxycycline can affect your life in various ways and might do more harm than good.

There’re always signs when things are going in the wrong direction, and if you look at those signs and reach out for help within time, you can stop things from worsening.

Consult your doctor and ask them as many questions possible about this drug even though they might let you know themselves.

As a consumer, it’s essential to know what’s going on in our system and how it might affect us!

Saumya Malik is an ardent follower of everything good for the health and wellness of body and mind. She's passionate about providing effective solutions to general health and mental well-being issues and wants to help people achieve the same. When not writing, you can find her curled up with a good book in a corner or cooking as a form of good mental therapy.
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